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T‐lymphocyte subpopulations in chronic lymphocytic leukemia: A quantitative and functional study
Author(s) -
Semenzato G.,
Pezzutto A.,
Agostini C.,
Albertin M.,
Gasparotto G.
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19811115)48:10<2191::aid-cncr2820481013>3.0.co;2-9
Subject(s) - antibody dependent cell mediated cytotoxicity , cytotoxic t cell , chronic lymphocytic leukemia , lymphocytosis , immunology , medicine , lymphocyte , population , immune system , leukemia , pokeweed mitogen , b cell , antibody , biology , concanavalin a , in vitro , monoclonal antibody , biochemistry , environmental health
In the peripheral blood of patients with chronic B‐cell lymphocytic leukemia (B‐CLL) absolute numbers of E‐rosetting lymphocytes were increased. The proportions of T G and T M cell subsets were analyzed, as were their effects on the pokeweed mitogen (PWM)‐dependent differentiation of normal allogenic B cells or of autologous leukemic cells. The T G lymphocyte subset was further studied for its cytotoxic activity in antibody‐dependent cellular cytotoxicity (ADCC). A marked increase both in percentages and in absolute numbers of T G cells was found. T M lymphocytes percentages were normal, but because of the T lymphocytosis occurring in all patients, the absolute numbers of T M were increased. T M and T G subsets showed helper and suppressor activity, respectively, in PWM‐induced B‐cell differentiation. T G cells displayed effector cell activity in ADCC. The results provide further evidence that T lymphocytes from patients with B‐CLL are functionally normal. However, a noticeable increase of the T‐cell subset having suppressor and cytotoxic activity in ADCC was observed. This may be the consequence of a normal immune reaction to the leukemic population.