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Effects of intralesional interferon on neuroblastoma: Changes in histology and DNA content distribution of tumor masses
Author(s) -
Sawada Tadashi,
Takamatsu Tetsuro,
Tanaka Terufusa,
Mino Masahiro,
Fujita Katsutoshi,
Kusunoki Tomoichi,
Arizono Naoki,
Fukuda Masaru,
Kishida Tsunataro
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19811115)48:10<2143::aid-cncr2820481004>3.0.co;2-6
Subject(s) - neuroblastoma , interferon , medicine , histology , cancer research , tumor cells , pathology , dna , cell culture , immunology , biology , biochemistry , genetics
Local injections of interferon, 30 × 10 4 IU, ten times, were found to reduce masses of neuroblastoma. Histologic findings and nuclear DNA measurements of cells from tumors in which interferon has been injected compared with cells from tumors that did not receive injections demonstrated that the reduction of neuroblastoma masses by interferon did not depend on increased cell differentiation or on interruption of tumor cell production. Although the mechanism of interferon's action on reducing neuroblastoma is unknown, the disappearance of tumor cells may be caused by high levels of interferon in tumor tissues.