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Multiple histologic subtypes of non‐Hodgkin's lymphoma: Clinical and pathologic features
Author(s) -
Leyser Selig,
Variakojis Daina,
Mintz Uri,
Vardiman James W.,
Ultmann John E.
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19811101)48:9<2063::aid-cncr2820480924>3.0.co;2-p
Subject(s) - medicine , lymphoma , biopsy , non hodgkin's lymphoma , survival rate , pathology , disease , radiology
Twenty patients with non‐Hodgkin's lymphoma (NHL) had different histologic subtypes of NHL in multiple sites or in a single tumor mass either at the time of their initial biopsy and staging (13 patients) or in the course of their disease (seven patients). These 20 cases represent 3.7% of all patients with NHL seen at the University of Chicago between January 1968 and May 1979. The five‐year actuarial survival rate for all 20 patients was 68%. For those 13 patients who had multiple histologic subtypes at the initial workup, the five‐year survival rate was 45%; for the seven patients who developed a new histologic subtype later in the course of the disease, the five‐year survival rate was 85%. In the latter group of patients, however, the initial biopsy specimens demonstrated better prognostic subtypes, and the median survival from the time of diagnosis of a new, less favorable histologic subtype averaged only four months. These findings indicate that the prognosis is related to the least favorable histologic subtype present, unless this is only a minor component of a composite lymphoma or is limited to one extranodal site.