Premium
Patterns of recurrence following curative resection alone for adenocarcinoma of the rectum and sigmoid colon
Author(s) -
Rao A. R.,
Kagan A. R.,
Chan P. M.,
Gilbert H. A.,
Nussbaum H.,
Hintz B. L.
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810915)48:6<1492::aid-cncr2820480636>3.0.co;2-k
Subject(s) - medicine , anaplasia , rectum , sigmoid colon , adenocarcinoma , concomitant , radiation therapy , distant metastasis , metastasis , surgery , cancer , pathology
Two‐hundred‐four patients with previously untreated adenocarcinoma of rectum, rectosigmoid, and sigmoid colon were retrospectively evaluated to determine patterns of recurrence following curative resection. Seventy‐eight (38%) subsequently developed recurrent disease. Of these, 40% (31/78) presented with local recurrence alone, 28% (22/78) with regional recurrence, 15% (12/78) with concomitant local recurrence and distant metastasis, and 17% (13/78) with distant metastasis alone. The degree of tumor anaplasia and depth of tumor penetration into the bowel wall influenced the rate of local recurrence. Through five years local recurrence without clinical evidence of distant metastasis was the most common cause of death. Need for adjuvant radiation therapy is discussed.