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Serous ovarian neoplastic amylase (SONA): A potentially useful marker for serous ovarian tumors
Author(s) -
Van Kley Harold,
Cramer Stewart,
Bruns David E.
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810915)48:6<1444::aid-cncr2820480628>3.0.co;2-e
Subject(s) - serous fluid , amylase , medicine , pathology , ovarian cyst , sephadex , serous cystadenoma , cyst , chemistry , enzyme , biochemistry
A series of cystic ovarian tumors was studied with regard to amylase activity in the cyst fluid. Large amounts of amylase activity were present only in those patients with endosalpingealtype lining epithelium (serous ovarian neoplasms). The amylase activity from two such patients was further characterized using G75 Sephadex chromatography, DEAE Sephadex chromatography, agarose gel chromatography, isoelectric focusing, and heat inactivation studies. Serous ovarian neoplastic amylase (SONA) exhibited properties different from amylases of pancreatic and salivary gland origin. Serous ovarian neoplastic amylase (SONA) may be a useful biochemical marker in diagnosing and managing patients with serous ovarian neoplasms.