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Osteosarcoma arising in heterotopic ossification of dermatomyositis: Case report and review of the literature
Author(s) -
Eckardt Jeffrry J.,
Ivins John C.,
Perry Harold O.,
Unni Krishnan K.
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810901)48:5<1256::aid-cncr2820480534>3.0.co;2-4
Subject(s) - medicine , dermatomyositis , heterotopic ossification , osteosarcoma , ossification , biopsy , calcinosis , calcification , surgery , dermatology , pathology
A patient with dermatomyositis developed malignant transformation of the benign interfascial heterotopic bone. This patient had classic childhood dermatomyositis at the age of 3 years, and the disease was arrested after a one‐year course of corticosteroid therapy. Extensive subcutaneous calcinosis cutis and deep interfascial calcinosis were the residua of the disease. Twenty‐eight years later, the patient developed a high‐grade osteosarcoma within the benign intermuscular heterotopic calcification and ossification that had been previously documented at the age of 8 years by a roentgenogram and at the age of 16 years by biopsy. This case represents the first report of the association of osteosarcoma and dermatomyositis, and possibly the first well‐documented case of malignant transformation of benign heterotopic bone.