Premium
Flow cytometry of breast carcinoma: I. Relation of DNA ploidy level to histology and estrogen receptor
Author(s) -
Olszewski Wlodzimierz,
Darzynkiewicz Zbigniew,
Rosen Paul Peter,
Schwartz Morton K.,
Melamed Myron R.
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810815)48:4<980::aid-cncr2820480421>3.0.co;2-7
Subject(s) - flow cytometry , medicine , estrogen receptor , histology , ploidy , estrogen , breast carcinoma , pathology , carcinoma , breast cancer , biology , cancer , immunology , genetics , gene
Flow cytometry studies of the DNA distribution of tumor cells from 92 human breast cancers showed measurable aneuploidy (hyperploidy) in 85 cases (92%). The DNA ploidy values were unimodal in each case, but there was a bimodal distribution for the entire series. One group of tumors had a diploid or near diploid DNA distribution and a second group had ploidy levels from triploid to tetraploid or higher. The tumors with lower DNA ploidy (at or near diploid) tended to be histologically low grade, cytologically more orderly and estrogen‐binding positive; those with higher DNA ploidy were more likely to be higher grade, more anaplastic, and estrogen‐binding negative.