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Monoblastic transformation in chronic myelogenous leukemia: Presentation with massive hepatic involvement
Author(s) -
Ondreyco Sharon M.,
Kjeldsberg Carl R.,
Fineman Robert M.,
Vaninetti Shan,
Kushner James P.
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810815)48:4<957::aid-cncr2820480418>3.0.co;2-6
Subject(s) - medicine , chronic myelogenous leukemia , transformation (genetics) , presentation (obstetrics) , leukemia , surgery , genetics , biology , gene
Monoblastic transformation developed in a 26‐year‐old white man with chronic myelogenous leukemia and was manifested by acute, fulminant hepatic failure due to massive blastic infiltration of the liver. The hepatic failure responded dramatically to radiation therapy. The monocytic origin of the blasts was confirmed by means of light and electron microscopic examination and cytochemical studies. Cytogenetic studies of the leukemic blasts revealed a Philadelphia‐chromsome‐positive karyotype and a clonal evolution of chromosome changes resulting in multiple karyotypes.