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Ultrastructural cytochemical prospective study of adult acute lymphoblastic leukemia: Detection of peroxidase activity in patients failing to respond to treatment
Author(s) -
Reiffers Josy,
Darmendrail Vivianne,
Larrue Jacky,
Villenave Isabelle,
Bernard Philippe,
Boisseau Michel,
Broustet Antoine
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810815)48:4<927::aid-cncr2820480412>3.0.co;2-r
Subject(s) - medicine , lymphoblastic leukemia , ultrastructure , peroxidase , pathology , leukemia , enzyme , biochemistry , biology
Ultrastructural cytochemical studies revealed peroxidase activity in five of 25 adult patients with apparent null lymphoblastic leukemia (ALL) in whom the peroxidase reaction studied with light microcopy was negative. None of these 5 patients responded to a chemotherapy regimen used for adult ALL. The importance of ultrastructural cytochemistry which allows the recognition of myeloblastic differentiation in undifferentiated blast cells is also demonstrated. The correct classification of such cases may be important for prognosis because they appear to be resistant to the chemotherapy used in treating ALL.