Premium
Glycosaminoglycans of pleural mesothelioma: A possible biochemical variant containing chondroitin sulfate
Author(s) -
Iozzo Renato V.,
Goldes Jeffrey A.,
Chen WeiJen,
Wight Thomas N.
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810701)48:1<89::aid-cncr2820480118>3.0.co;2-b
Subject(s) - glycosaminoglycan , mesothelioma , hyaluronic acid , chondroitin sulfate , chondroitin , medicine , pathology , biochemistry , chemistry , anatomy
Glycosaminoglycans of a malignant pleural mesothelioma have been characterized histochemically and biochemically and compared with those of normal lung, pleural plaque, lung carcinoma, and other connective tissue neoplasms. Chondroitin sulfate constituted the major glycosaminoglycan (∼80% of total) present in the pleural mesothelioma while hyaluronic acid was present in only trace amounts (∼3% of total). In particular chondroitin 6‐sulfate was the predominant isomer, constituting 80% of the total chondroitin sulfate. Control tissue exhibited different proportions of glycosaminoglycans and none of them contained as high an absolute concentration of chondroitin sulfate as the mesothelioma. These findings differ from previous reports demonstrating increased concentration of hyaluronic acid in mesothelioma and suggest the possible existence of a biochemically different form of this neoplasm.