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A linkage study of HLA and inherited adenocarcinoma of the colon
Author(s) -
Sivak Michael V.,
Sivak Donna Schleutermann,
Braun William A.,
Sullivan B. H.
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810701)48:1<76::aid-cncr2820480116>3.0.co;2-r
Subject(s) - medicine , colorectal cancer , human leukocyte antigen , cancer , adenocarcinoma , linkage (software) , typing , genetic linkage , genetics , oncology , immunology , biology , gene , antigen
A kindred with the familial cancer syndrome is reported in which every confirmed affected member of the pedigree had at least one primary carcinoma of the colon. The average age at which cancer appeared was 38 years, and multiple primary neoplasms occurred in 23% of the cancer patients. Transmission of the cancer trait is consistent with an autosomal dominant mode of inheritance. Colonoscopy eliminated the presence of any unsuspected cancers in family members at risk. HLA typing was done, and by direct typing or inference, data were available on 66 living and deceased individuals. There were four informative matings in the kindred, the offspring of which showed only three crossovers of a possible 17. The lod score totaled 1.06 at a recombination fraction of 0.20. The need for cooperative efforts of many investigators in HLA linkage studies is emphasized, along with the potential value of such an approach.