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Intraarterial cis‐platinum for patients with inoperable skeletal tumors
Author(s) -
Mavligit G. M.,
Benjamin R.,
Patt Y. Z.,
Jaffe N.,
Chuang V.,
Wallace S.,
Murray J.,
Ayala A.,
Johnston S.,
Hersh E. M.,
Calvo D. B.
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810701)48:1<1::aid-cncr2820480102>3.0.co;2-r
Subject(s) - medicine , hemipelvectomy , surgery , biopsy , chemotherapy , radiology , amputation
Twenty‐three patients with inoperable skeletal tumors were treated with intraarterial cis‐platinum prior to attempted surgery. The antitumor effect of intraarterial cis‐platinum was monitored clinically by radiologic imaging techniques and, whenever possible, evaluated histopathologically by examination of surgical or biopsy tumor specimens. Objective responses were noted in 12 patients (52%) and included 2 complete, 7 partial and 3 less‐than‐partial remissions lasting from 14 to 70 weeks. Limb‐saving surgery or hemipelvectomy became subsequently feasible in four and one patients respectively. Preoperative intraarterial cis‐platinum is a safe procedure which might be used effectively in combination with other, more conventional postoperative adjuvant chemotherapy against skeletal tumors.