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Elevated vitamin levels in colon adenocarcinoma as compared with metastatic liver adenocarcinoma from colon primary and normal adjacent tissue
Author(s) -
Baker Herman,
Frank Oscar,
Chen Thomas,
Feingold Susan,
Deangelis Barbara,
Baker Elliott R.
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810615)47:12<2883::aid-cncr2820471222>3.0.co;2-i
Subject(s) - medicine , adenocarcinoma , vitamin , vitamin b12 , colorectal cancer , gastroenterology , endocrinology , pathology , cancer
Twenty‐four samples of colon adenocarcinoma removed at surgery and autopsy together with adjacent uninvaded normal colon from the same subjects were analyzed for vitamin B 12 and B 6 , biopterin, nicotinate, riboflavin, pantothenate, thiamin, biotin, and folates. Nine specimens of metastatic liver adenocarcinoma from colon primary together with adjacent uninvaded normal liver were also analyzed for these same vitamins. Primary colon adenocarcinoma contains significantly ( p < 0.001) more of the above vitamins than normal colon; 1.8‐ to 3.5‐fold higher concentrations of vitamins were found in this tumor. In contrast, vitamin B 12 levels were almost two‐fold lower. Unlike colon tumor, metastatic liver adenocarcinoma from colon primary contained from 1.2‐ to 28‐fold lower vitamin concentration than normal liver tissue. The present findings suggest that those types of primary tumors with conspicuously high vitamin content needed for the enhanced growth and catalysis of tumor metabolism may be arrested with antivitamins targeted at metabolic sites other than those involved with nucleic acid synthesis.