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The pathology of gamma heavy chain disease: Report of a case with morphologic progression from lymphocytic to plasmacytic proliferation
Author(s) -
Marsh William L.,
Worthman John W.,
Spiegelberg Hans L.
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810615)47:12<2878::aid-cncr2820471221>3.0.co;2-7
Subject(s) - pathology , medicine , bone marrow , lymph , disease , lymph node
Gamma heavy chain disease is an uncommon disorder characterized by the secretion of abnormal fragments of the gamma heavy chain in serum and urine. Most of the studies of gamma heavy chain disease have focused on the abnormal protein; relatively little information is available on the pathologic findings. This paper reports a patient with gamma heavy chain disease whose bone marrow and lymph nodes showed a morphologic progression from a lymphocytic to plasmacytic proliferation. The English language literature on gamma heavy chain disease is reviewed with respect to pathologic findings in lymph nodes, bone marrow, and peripheral blood.