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Immunodeficiency, pulmonary lymphoreticular infiltration, paraproteinemia, and terminal lymphoma
Author(s) -
Richmond J. M.,
Dawkins R. L.,
Henderson D. W.,
Tan N. T. S.
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810601)47:11<2641::aid-cncr2820471120>3.0.co;2-e
Subject(s) - paraproteinemia , medicine , pathology , lymphoma , infiltration (hvac) , macroglobulinemia , monoclonal , lung , immunology , monoclonal antibody , multiple myeloma , antibody , physics , thermodynamics
A 64‐year‐old woman was found to have pulmonary lymphoreticular infiltration associated with a cryoprecipitate monoclonal paraprotein. History and investigation suggested that these features may have complicated long‐standing immunodeficiency. Subsequent postmortem revealed a lymphocytic lymphoma of the lung and stomach. It is postulated that pulmonary lymphoreticular infiltration and monoclonal paraproteinemia might be a consequence of defective immunoregulation with excessive B cell proliferation. The eventual lymphoma is thought to represent malignant transformation.