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Pseudoneoplastic proliferation of endocrine cells in pancreatic fibrosis
Author(s) -
Bartow Sue A.,
Mukai Kiyoshi,
Rosai Juan
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810601)47:11<2627::aid-cncr2820471118>3.0.co;2-c
Subject(s) - medicine , endocrine system , fibrosis , hyperplasia , pathology , atrophy , pancreas , pancreatic duct , enteroendocrine cell , pancreatic disease , hormone
Twenty cases of florid pancreatic endocrine neoformation and hyperplasia in a background of pancreatic fibrosis were culled from a review of 70 cases of pancreatic fibrosis, atrophy, chronic inflammation, and duct obstruction and 29 cases of pancreatic islet cell hyperplasia and neoplasia. Three of these cases had morphologic features suggestive of neoplasia. The phenomenon of endocrine tissue proliferation in a setting of exocrine tissue destruction and fibrosis, especially that secondary to major exocrine duct obstruction is reviewed. The criteria for diagnosis of endocrine neoplasia vs. hyperplasia and the attendant biologic continuum, including applicability of immunohistochemical studies, are discussed.