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The morphologic effects of mitomycin c in mammalian urinary bladder
Author(s) -
Murphy William M.,
Soloway Mark S.,
Crabtree William N.
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810601)47:11<2567::aid-cncr2820471109>3.0.co;2-9
Subject(s) - mitomycin c , medicine , pathology , cytology , urinary bladder , necrosis , thiotepa , urinary system , drug , cancer research , pharmacology , urology , surgery , chemotherapy , cyclophosphamide
This investigation was intended to determine the morphologic changes of mitomycin C. It is part of a series of experiments designed to evaluate the cytologic and histologic effects of topical chemotherapeutic agents using the FANFT experimental model system in mice. The results for mitomycin C are very similar to those previously reported for thio‐tepa. They indicate that these chemicals produce few, if any, drug‐specific light microscopic alterations. Rather, mitomycin C and thio‐tepa apparently act as toxic substances, causing increased exfoliation, degeneration, and necrosis of urothelial cells. The implications of these findings and suggestions for future investigations are discussed.