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Glioblastoma multiforme following prophylactic cranial irradiation and intrathecal methotrexate in a child with acute lymphocytic leukemia
Author(s) -
Chung C. K.,
Stryker John A.,
Cruse Robert,
Vannuci Robert,
Towfighi Javad
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810601)47:11<2563::aid-cncr2820471108>3.0.co;2-o
Subject(s) - medicine , methotrexate , prophylactic cranial irradiation , acute lymphocytic leukemia , leukemia , glioma , chemotherapy , radiation therapy , glioblastoma , pathology , surgery , lymphoblastic leukemia , cancer research , myocardial infarction , conventional pci
Cases of radiation‐induced glioma in humans are extremely rare. A 2‐year‐old boy with acute lymphocytic leukemia had received prophylactic cranial irradiation (2400 rad/2 1/2 weeks) and intrathecal methotrexate. Five years later he developed a glioblastoma multiforme on the left cerebral hemisphere while the leukemia was in remission. This is the first reported association of these disorders. It is possible that the glioma may have been induced by radiation and/or chemotherapy.