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A high level of glycosaminoglycan‐synthesis of squamous cell carcinoma of the parotid gland
Author(s) -
Takeuchi Jun,
Sobue Mitsuko,
Yoshida Masahiko,
Uchibori Noriyasu,
Sato Emiko,
Miura Kaoru
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810415)47:8<2030::aid-cncr2820470822>3.0.co;2-u
Subject(s) - glycosaminoglycan , hyaluronic acid , pathology , carcinoma , cell , cell culture , epithelium , parotid gland , hela , basal cell , medicine , chemistry , biology , biochemistry , anatomy , genetics
Glycosaminoglycan content of a squamous cell carcinoma derived from the parotid gland was analyzed. The tumor tissue contained a large amount of glycosaminoglycans, and the amount was strikingly larger than found in other kinds of tumor tissues (pleomorphic adenoma, scirrhous carcinoma, myxoma, etc.) analyzed previously. A culture cell line established from this tumor showed a morphologic characteristic of differentiated squamous cell carcinoma, in vitro , forming many tonofilaments in the cytoplasm and numerous desmosomes in the intercellular connection. The carcinoma cell synthesized and secreted a large amount of glycosaminoglycans, consisting mainly of hyaluronic acid. The amount of 3 H‐labelled hyaluronic acid secreted by this carcinoma cell was about 20‐fold larger than that by HeLa cell or KB cell. Conceivably, a high level of hyaluronic acid synthesis is one of the biologic characteristics of squamous cell carcinoma derived from the duct epithelium of the salivary gland.