Premium
Precursors of human colon carcinoma: A serial section study of colectomy specimens
Author(s) -
Lev Robert,
Grover Robert
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810415)47:8<2007::aid-cncr2820470818>3.0.co;2-w
Subject(s) - medicine , adenocarcinoma , carcinoma , colectomy , pathology , hyperplastic polyp , adenomatous polyps , colorectal cancer , dysplasia , frozen section procedure , epithelium , gastroenterology , cancer , colonoscopy
All polyps and strips of colonic mucosa 1 to 15 cm from tumor margins were examined for possible precursors of carcinoma in 24 patients undergoing partial colectomy for primary colorectal adenocarcinoma. Of 114 polyps found, 40.4% were adenomatous, and the remainder were hyperplastic or inflammatory or showed normal mucosa. No primarily dysplastic lesions, which could be interpreted as early de novo carcinomas, were found. Serial sections of mucosal strips revealed minute adenomatous foci in 3 of 24 patients, one of whom also showed several patches of exclusively dysplastic epithelium. This finding suggests that carcinomas may rarely arise de novo , but most carcinomas appear to be accompanied by (? preceded by) adenomatous changes.