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Specific immunotherapy of advanced renal carcinoma: Evidence for the polyclonality of metastases
Author(s) -
McCune Craig S.,
Schapira David V.,
Henshaw Edgar C.
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810415)47:8<1984::aid-cncr2820470814>3.0.co;2-j
Subject(s) - medicine , immunotherapy , renal cell carcinoma , ambulatory , toxicity , oncology , carcinoma , surgery , urology , cancer
Autologous, irradiated (10,000 rads) tumor cells mixed with C. parvum were given weekly to 14 patients with metastatic renal carcinoma. The tumor tissue had been cryopreserved with DMSO. No significant toxicity was produced. Four patients underwent objective responses, and a fifth had prolonged stabilization (27+ months). Varying responses occurred simultaneously in different metastatic lesions within the same patient. Responding patients usually had an excellent ambulatory status and received greater than 20 × 10 7 tumor cells.