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Electron microscopy of E‐rosette‐forming leukemic monocytes in a child with acute monocytic leukemia
Author(s) -
Tsukada Masahige,
Saitoh Hiroharu,
Hara Toshihiro,
Komiyama Atsushi,
Akabane Taro
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810401)47:7<1800::aid-cncr2820470713>3.0.co;2-p
Subject(s) - rosette (schizont appearance) , acute monocytic leukemia , monocyte , ultrastructure , rosette formation , precursor cell , leukemia , pathology , monocytic leukemia , myeloid , medicine , myeloid leukemia , electron microscope , peripheral blood , immunology , cell , biology , biochemistry , antibody , physics , optics
A 7‐year‐old boy with acute monocytic leukemia (AMoL) had leukemic monocytes that formed spontaneous rosettes with sheep red blood cells (E‐rosette). The E‐rosette formation was observed in 75% of leukemic monocytes at 4 C and in 37% at 37 C. Cytochemical and ultrastructural studies confirmed that the rosette‐forming cells were leukemic monocytes. The leukemic monocytes attached to the red blood cells at a portion of their surface and did not show any phagocytic processes at the electron microscopic level. The data from this patient seem to indicate that in a rare case of AMoL, abnormal myeloid lymphoid stem cells can differentiate to monocytes while retaining lymphoid properties.