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Normal computed tomograms of the brain in osteosarcoma patients treated with high‐dose methotrexate
Author(s) -
Bowles Debbie,
Pratt Charles,
Evans William,
Price Robert A.,
Coburn Thomas
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810401)47:7<1762::aid-cncr2820470706>3.0.co;2-8
Subject(s) - medicine , methotrexate , cyclophosphamide , osteosarcoma , complication , chemotherapy , neurotoxicity , computed tomography , radiation therapy , radiology , surgery , nuclear medicine , toxicity , pathology
Eighteen patients with osteosarcoma, most of whom were adolescents, were examined for abnormalities of the brain by use of computed axial tomography. These studies were performed at 15–60 months (median 47 months) after the completion of adjuvant chemotherapy, which included high‐dose methotrexate, cyclophosphamide, and Adriamycin. No abnormalities were found. The results of this study, together with the absence of brain lesions in published reports in children receiving high‐dose methotrexate but no cranial irradiation, indicate that delayed neurotoxicity is not a major complication of this form of therapy in older children.