Premium
Hormone production by cultures of small‐cell carcinoma of the lung
Author(s) -
Sorenson G. D.,
Pettengill O. S.,
BrinckJohnsen T.,
Cate C. C.,
Maurer L. H.
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810315)47:6<1289::aid-cncr2820470610>3.0.co;2-b
Subject(s) - hormone , medicine , endocrinology , somatostatin , calcitonin , neurophysins , prolactin , luteinizing hormone , vasopressin , peptide hormone , cell culture , relaxin , biology , genetics
Continuous cell lines have been established from a variety of biopsy and postmortem species of tumor from patients with small‐cell carcinoma of the lung (SCCL) and have been maintained over several years. The medium from the cultures has been assayed for peptide, glycoprotein, and steroid hormones. Significant amounts of 14 hormones including calcitonin, adrenocorticotropin (ACTH), parathormone, luteinizing hormone, chorionic gonadotropin, glucagon, growth hormone, somatostatin, prolactin, β‐endorpin, lipotropin, oxytocin‐neurophysin, vasopressin‐neurophysin, and estradiol have been demonstrated. Up to ten different hormones have been produced by a single cell line. Most produce ACTH and all evaluated so far produce estradiol. These studies indicate that cells from SCCL have a potential for producing a wide variety of hormones and that this characteristic can be maintained for prolonged periods of culture in vitro .