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Effects of gastrointestinal hormones on pancreatic growth
Author(s) -
Johnson Leonard R.
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810315)47:6+<1640::aid-cncr2820471430>3.0.co;2-s
Subject(s) - secretin , cholecystokinin , gastrin , medicine , duodenum , endocrinology , gastrointestinal hormone , hormone , pancreas , endogeny , pancreatic polypeptide , peptide hormone , glucagon , secretion , receptor
This article discusses experiments demonstrating that the gastrointestinal hormones, gastrin, secretin, and CCK (cholecystokinin), stimulate the growth of the exocrine pancreas. Exogenous gastrin, secretin, and CCK increase pancreatic weight DNA, RNA and protein content of the rat pancreas. Antrectomy, which removes most endogenous gastrin, decreases pancreatic growth. The effects of antrectomy are prevented by exogenous gastrin. Infusion of HCI into the duodenum to release secretin and infusion of amino acids into the duodenum to release CCK also stimulate pancreatic growth. These results provide evidence that the regulation of pancreatic growth is an important action of the gastrointestinal hormones.

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