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Binding of N‐nitroso carcinogens in pancreatic tissue
Author(s) -
Woolley Paul V.,
Pinsky Seth D.
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810315)47:6+<1485::aid-cncr2820471408>3.0.co;2-v
Subject(s) - pancreas , carcinogen , nitroso compounds , chromatin , medicine , distribution (mathematics) , dna , organelle , cancer research , biochemistry , microbiology and biotechnology , chemistry , biology , mathematical analysis , mathematics , organic chemistry
Carcinoma of the pancreas can be produced in guinea pigs by the oral administration of 1‐methyl‐1‐nitrosourea (MNU). Our present studies have examined the distribution of this compound in these animals following parenteral and oral administration and also its specific sites of binding within the pancreatic cell. Emphasis has been placed upon the comparison of the uptake and binding of MNU with the related compound 1‐methyl‐3‐nitro‐1‐nitrosoguanidine (MNNG), which does not seem to be carcinogenic to the pancreas after oral administration. The distribution data indicate uptake into pancreas that is comparable to that of other organs. Binding data show both MNU and MNNG to extensively modify subcellular organelles and the DNA and proteins of chromatin, but that MNU does this to a somewhat greater extent than MNNG.