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Drug‐induced cancer
Author(s) -
Hoover Robert,
Fraumeni Joseph F.
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810301)47:5+<1071::aid-cncr2820471304>3.0.co;2-7
Subject(s) - medicine , cancer , drug , intensive care medicine , public health , cancer prevention , clinical practice , pharmacology , family medicine , pathology
This report reviews the medicinal agents that have been linked to human cancer, with emphasis on recent evidence implicating estrogenic compounds such as DES, menopausal estrogens, and oral contraceptives. Attention is also given to drugs that have fallen under suspicion and requires further epidemiologic evaluation. The detection of drug‐cancer associations not only influences clinical and public health practice, but may also provide insights into mechanisms of carcinogenesis. The clinician contributes to the prevention of drug‐induced cancer by being alert to iatrogenic hazards and cooperating in epidemiologic investigations, by weighing risks versus benefits in individual cases, and by discussing with patients the rationale and risks of proposed forms of therapy. Cancer 47:1071–1080, 1981.