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Neurosecretory granules in small cell invasive carcinoma of the urinary bladder
Author(s) -
Cramer Stewart F.,
Aikawa Masamichi,
Cebelin Marilyn
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810215)47:4<724::aid-cncr2820470417>3.0.co;2-2
Subject(s) - medicine , histogenesis , cystoscopy , urinary bladder , urinary system , pathology , irritability , carcinoma , hypophosphatemia , urology , anatomy , immunohistochemistry , menopause
A 69‐year‐old man showed symptoms of urinary bladder irritability and hematuria. Cystoscopy and radiographic studies revealed a tumor within a bladder diverticulum. The tumor shared histologic and ultrastructural features with oat cell carcinoma of the lung, including the presence of small numbers of neurosecretory type granules. In spite of conservative surgical treatment, there has been no evidence of recurrent or metastatic tumor over 14 months of follow‐up. Hypophosphatemia was present pre‐operatively, but resolved spontaneously after tumor resection. In regard to histogenesis, a metaplastic origin is favored. This appears to be the first reported case of a neoplasm of Kultschitzky‐type cells arising in the urinary bladder.