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Adriamycin/cis‐platinum/cyclophosphamide combination chemotherapy for advanced carcinoma of the parotid gland
Author(s) -
Alberts David S.,
Manning Michael R.,
Coulthard Stanley W.,
Koopmann Charles F.,
Herman Terence S.
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810215)47:4<645::aid-cncr2820470404>3.0.co;2-a
Subject(s) - medicine , cyclophosphamide , parotid gland , chemotherapy , oncology , carcinoma , pathology
Five patients were treated with a combination of Adriamycin/cis‐platinum/cyclophosphamide for faradvanced and/or recurrent cancers of the salivary gland. Adriamycin, 40 mg/m 2 , and cis‐platinum, 50 mg/m 2 , were given on day 1; cyclophosphamide, 200 mg/m 2 daily for four days, was given by mouth on the third to sixth day of each monthly therapy course. Two patients achieved a complete remission, each lasting five months, and the three others had partial remissions from one to seven months (median six months) in duration. Therapy was well tolerated. Severe nausea and vomiting occurred on the first day of therapy but was self‐limited. There was only mild to moderate leukopenia, no significant thrombo‐cytopenia or elevations of serum creatinine, and no evidence of dose‐limiting peripheral neuropathy. Adriamycin/cis‐platinum/cyclophosphamide chemotherapy appears to be effective in the treatment of advanced parotid gland cancers.