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Squamous cell carcinoma in dominant type epidermolysis bullosa dystrophica
Author(s) -
Schwartz Robert Allen,
Birnkrant Arthur P.,
Rubenstein Daniel Jay,
Kim Untae,
Burgess Gordon H.,
Stoll Howard L.,
Chai Soon W.,
Southwick Graeme J.,
Milgrom Halina
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810201)47:3<615::aid-cncr2820470332>3.0.co;2-t
Subject(s) - epidermolysis bullosa dystrophica , medicine , anchoring fibrils , dermatology , basal lamina , basal cell , epidermolysis bullosa , scars , pathology , genetic disorder , basal cell carcinoma , disease , basement membrane , ultrastructure
The unusual genetic disorder epidermolysis bullosa dystrophica has been reported in several patients in whom the chronic cutaneous scars led to the development of cutaneous squamous cell carcinoma. However, only one of these previously reported cases involved the autosomal dominant form of the disease; the remainder occurred in its recessive counterpart. We report the second and third patients with squamous cell carcinoma associated with the dominant form of epidermolysis bullosa dystrophica. In addition, we not only observed the previous electron microscopic findings of decreased numbers of anchoring fibrils beneath the basal lamina but have also noted marked disruption of the basal lamina itself.