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Electron microscope cytochemical analysis of chronic myelocytic leukemia: A case report
Author(s) -
Weiselberg Lora,
Teichberg Saul,
Vinciguerra Vincent,
Schulman Philip,
Budman Daniel,
Degnan Thomas
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810201)47:3<533::aid-cncr2820470318>3.0.co;2-k
Subject(s) - cytochemistry , pathology , ultrastructure , electron microscope , blast crisis , myelocytic leukemia , terminal deoxynucleotidyl transferase , bone marrow , precursor cell , biology , medicine , cell , leukemia , immunohistochemistry , immunology , biochemistry , optics , physics , tunel assay
A patient with Philadelphia chromosome positive CML was studied to characterize the blast transformation. Peripheral blood and bone marrow at the onset of the blast crisis were evaluated with cytochemistry, chromosome analysis, cell surface markers, terminal transferase assay, and electron microscopy. Although light microscopic examination and cytochemistry suggested lymphoblastic morphology, ultrastructural cytochemistry demonstrated the myelomonocytic features of the transformation. This study suggests that electron microscopic cytochemistry is useful in evaluating the heterogeneous nature of the blast phase of CML.