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Systemic hypertension: A complication of intra‐arterial cis‐diammine dichloroplatinum (II) infusion
Author(s) -
Kletzel Morris,
Jaffe Norman
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810115)47:2<245::aid-cncr2820470207>3.0.co;2-q
Subject(s) - medicine , discontinuation , complication , surgery , anesthesia
Intra‐arterial Cis‐diammine dichloroplatinum (II) administered to five patients produced systemic and sustained hypertension in four of them. This finding persisted for six months despite discontinuation of the drug. This complication has not been observed in patients receiving the drug by the intravenous route. Possible etiologic factors are discussed.