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Pineal astrocytoma: Report of a case, confined to the epiphysis, with immunocytochemical and electron microscopic studies
Author(s) -
Papasozomenos Sozos,
Shapiro Susan
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810101)47:1<99::aid-cncr2820470117>3.0.co;2-z
Subject(s) - immunostaining , pathology , astrocytoma , pineal gland , glial fibrillary acidic protein , autopsy , medicine , neoplasm , immunohistochemistry , antiserum , ultrastructure , anatomy , endocrinology , antibody , cancer research , glioma , immunology , melatonin
A low‐grade astrocytoma confined to the pineal gland is reported. The neoplasm was incidentally found at autopsy in a 39‐year‐old white female with no neurologic symptoms. The astrocytic origin of the neoplasm has been confirmed with electron microscopic studies and with peroxidase‐antiperoxidase immunostaining, using an antiserum raised against the glial fibrillary acidic (GFA) protein. This is the first published case of a well‐documented astrocytoma limited to the pineal. The presence of apparently normal, GFA protein‐containing cells in human pineal gland is also demonstrated for the first time.