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Heterotransplantation of nb rat prostatic adenocarcinomas into congenially athymic nude mice: Chemotherapy of autonomous tumors
Author(s) -
Drago Joseph R.,
Gershwin M. Eric
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810101)47:1<55::aid-cncr2820470111>3.0.co;2-w
Subject(s) - cyclophosphamide , medicine , methotrexate , prostatic adenocarcinoma , chemotherapy , adenocarcinoma , prostate , pathology , oncology , urology , cancer
Although Nb rat prostatic adenocarinoma rarely occurs spontaneously, the frequency of occurrences is increased by hormone induction. In this study, the Nb rat autonomous prostatic adenocarcinomas, Pr‐90 and 13‐Pr‐12, were heterotransplanted into congenially athymic (nude) mice for the purpose of evaluating the response of these tumors to chemotherapeutic agents. Adriamycin and methotrexate were evaluated in treating both tumors, and cyclophosphamide and BCNU + 5 FU were evaluated in 13‐Pr‐12. This paper reviews the treatment of autonomous tumors at varying tumor volume, as well as the use of chemotherapeutic modalities at various dosage levels. Significance was observed in animals treated with cyclophosphamide, as well as methotrexate, and at the highest dose of Adriamycin ( P < 0.05). Complete tumor regression and marked tumor volume decrease were observed in animals treated with cyclophosphamide and methotrexate. Recent reports have led to some optimism in treating human prostatic adenocarcinomas with Adriamycin and cyclophosphamide.