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Breast cancer after hodgkin's disease in two sisters
Author(s) -
Li Frederick P.,
Corkery Joseph,
Canellos George,
Neitlich Harvey W.
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19810101)47:1<200::aid-cncr2820470132>3.0.co;2-x
Subject(s) - medicine , breast cancer , oncology , disease , family history , lymphoma , cancer
Two sisters had breast cancer at four years and 11 years after diagnosis of Hodgkin's disease. The affected breast tissues had received several hundred rads of scatter radiation during treatment of the lymphoma. Family history revealed breast cancer in a third sister and five other women in the paternal line. Cytogenetic and HLA studies showed no markers of susceptibility to neoplasia. Development of second primary neoplasms of the breast in the two sisters may have resulted from interactions between genetic factors and carcinogenic effects of radiation exposure.