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Bone sarcoma as a second malignant neoplasm in children: Influence of radiation and genetic predisposition
Author(s) -
Meadows Anna T.,
Strong Louise C.,
Li Frederick P.,
D'Angio Giulio J.,
Schweisguth Odile,
Freeman Arnold I.,
Jenkin R. D. T.,
MorrisJones Patricia,
Nesbit Mark E.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19801215)46:12<2603::aid-cncr2820461212>3.0.co;2-4
Subject(s) - medicine , osteosarcoma , sarcoma , genetic predisposition , chondrosarcoma , neoplasm , cancer , mutation , radiation therapy , etiology , pathology , oncology , disease , genetics , biology , gene
Osteosarcoma or chondrosarcoma developed as a second malignant neoplasm (SMN) in 40 of 188 individuals with SMN whose first neoplasm occurred in childhood. A genetic susceptibility to cancer was found in 23; the SMN developed in an irradiated field in 32; both factors were present in 16; neither in one. When a genetic predisposition was present, radiation shortened the interval to SMN. The intervals between tumors and the age at which the bone sarcomas developed in relation to genetic disease and therapy were analyzed by a two‐mutation hypothesis. Studies of SMN in childhood permit us to make observations about the role of genetic factors and environmental mutagens in cancer etiology.