Premium
Correlation of estrogen and progesterone receptors with histologic differentiation in mammary carcinoma
Author(s) -
McCarty Kenneth S.,
Barton Thomas K.,
Fetter Bernard F.,
Woodard Brett H.,
Mossler Jeffrey A.,
Reeves William,
Daly John,
Wilkinson William E.,
McCarty Kenneth S.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19801215)46:12+<2851::aid-cncr2820461424>3.0.co;2-k
Subject(s) - progesterone receptor , grading (engineering) , estrogen , medicine , estrogen receptor , mammary gland , receptor , pathology , carcinoma , hormone receptor , endocrinology , cancer , breast cancer , biology , ecology
Using a modification of the histologic grading system of the NSABP, we observed a trend towards higher levels of estrogen (E 2 R) and progesterone receptor (PR) content in well (grade I) and moderately (grade II) differentiated mammary carcinomas. This relationship between receptor content and histologic grade is enhanced by considering estrogen and progesterone receptor simultaneously. The rank correlation between the quantitative levels of E 2 R and PR was 0.74 among histologic grade I tumors and 0.64 among histologic grade II tumors. Among the grade III carcinomas, the majority of tumors displayed either a paucity of measurable receptor or a divergence between levels of estrogen versus progesterone receptor (r = 0.19). The use of ultrastructural evaluation of features of differentiation is discussed in the evaluation of grade III tumors and in the evaluation of specific histologic types of mammary carcinoma.