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Chromosomes and causation of human cancer and leukemia: XL. The Ph 1 and other translocations in CML
Author(s) -
Sandberg Avery A.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19801115)46:10<2221::aid-cncr2820461019>3.0.co;2-8
Subject(s) - chromosomal translocation , chromosome , genetics , biology , philadelphia chromosome , gene
To date, 85 cases with unusual Ph 1 translocations have been described and are summarized in the present report of the 85 translocations, 41 were simple and 44 complex. Only chromosomes #1, #4, #8, and #20 and the Y have not been found to be involved in simple translocations and #12, #16, #18, #20 and the Y in complex ones. Chromosomes #18, #20, and Y have not been involved to date in either complex or simple Ph 1 translocations. Four cases have been reported in whom more than three chromosomes were involved in the Ph 1 translocation and only four cases in whom the #9 was not involved in complex Ph 1 translocations. The chromosomal changes, in addition to the Ph 1 , accompanying unusual Ph 1 translocations in CML are not different from those seen in cases with the standard type of Ph 1 translocation. Translocations (other than the Ph 1 ) in CML occur in less than 1% of the cases and, to date, have been found to involve all the chromosomes except the X and Y. With rare exceptions, in complex Ph 1 translocations 1) the distal end of #22 is translocated to a third chromosome ( i.e. , other than #9), a part of which is translocated to #9, #2) the breaks in the involved chromosomes probably occur concomitantly, and 3) a characteristic Ph 1 chromosome is present. The survival of patients with CML and unusual or complex Ph 1 translocations does not differ significantly from that of patients with the standard Ph 1 ‐translocation.