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Intraoperative radiotherapy for advanced carcinoma of the biliary system
Author(s) -
Todoroki Takeshi,
Iwasaki Yoji,
Okamura Takao,
Nagoshi Kazuo,
Asakura Hideo,
Nakano Masayuki,
Inada Tetsuo,
Tsunemoto Hiroshi,
Umegaki Yoichiro,
Nishimura Akira,
Nakano Masao,
Sato Hiroshi
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19801115)46:10<2179::aid-cncr2820461014>3.0.co;2-y
Subject(s) - medicine , radiation therapy , bile duct carcinoma , carcinoma , bile duct , lesion , cholangiography , radiology , gallbladder , intraoperative radiation therapy , surgery
Abstract Since November 1973, intraoperative radiotherapy has been performed on five patients with unresectable, advanced carcinoma of the bile duct at the hepatic hilus and six patients with unresectable carcinoma of the gallbladder. A treatment cone with a diameter ranging from 4–10 cm was directly applied at the lesion. A single dose of 2500–3000 rad with 11 to 20 meV electrons was delivered. In all patients, recanalization of the obstructed bile duct was observed by the postoperative cholangiography. The local efficacy was confirmed histopathologically in eight autopsied materials and a specimen resected 105 days after radiotherapy. Mean survival time of patients with unresectable tumors was 10.9 ± 5.6 (SD) months after this radiotherapy. Intraoperative radiotherapy increased the effectiveness and length of palliation for the unresectable lesion.