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Treatment of advanced cervical cancer by combination of bleomycin and mitomycin‐C
Author(s) -
Krebs HansB.,
Girtanner Robert E.,
Nordqvist Staffan R. B.,
Mineau Irene,
Frederick Helmkamp B.,
Averette Hervy E.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19801115)46:10<2159::aid-cncr2820461009>3.0.co;2-m
Subject(s) - medicine , bleomycin , regimen , mitomycin c , complete remission , chemotherapy , cervical cancer , surgery , combination chemotherapy , complete response , clinical trial , cancer
A combination of bleomycin and mitomycin‐C, reported as extraordinarily effective in a previous clinical trial, was used to treat 20 patients with advanced cervical cancer. Seven partial remissions (35%) and one complete remission (5%) were observed. Six of the partial remissions were of short duration (less than four months); the only patient with complete remission was still alive without evidence of disease ten months after initiation of chemotherapy. Nonresponders had a mean survival time of 6.6 months and responders 8.0 months. The treatment results confirm some efficacy of the drug regimen, although in our hands it did not live up to the high expectations raised by others.