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Retinoblastoma: The case for radiotherapy and for adjuvant chemotherapy
Author(s) -
Freeman C. R.,
Esseltine DL.,
Whitehead V. M.,
Chevalier L.,
Little J. M.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19801101)46:9<1913::aid-cncr2820460904>3.0.co;2-h
Subject(s) - medicine , retinoblastoma , radiation therapy , chemotherapy , disease , presentation (obstetrics) , surgery , eye disease , pediatrics , biochemistry , chemistry , gene
The results of treatment for 39 consecutive children with retinoblastoma that was diagnosed between 1951 and 1978 were analyzed. Failure to achieve local control within the eye and the development of metastatic disease occurred in seven patients. These patients are considered individually. Delay in diagnosis, older age at presentation, and extraocular extension of disease at diagnosis were associated with treatment failure and were closely interrelated. Modified radiotherapy techniques using wider fields may prevent failure even in those cases diagnosed late and in those with extraocular extension. Indications for intrathecal and systemic chemotherapy in this disease are discussed.