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Neuroblastoma: Influence of age at diagnosis, stage, tumor site, and sex on prognosis
Author(s) -
Coldman A. J.,
Fryer C. J. H.,
Elwood J. M.,
Sonley M. J.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19801015)46:8<1896::aid-cncr2820460833>3.0.co;2-y
Subject(s) - medicine , neuroblastoma , stage (stratigraphy) , pediatrics , survival analysis , demography , paleontology , genetics , sociology , biology , cell culture
A study of a consecutive series of 99 children with neuroblastoma seen at two major Toronto hospitals between 1951 and 1971 is reported. The children who were aged 24 months or less at diagnosis showed an overall two‐year survival rate of 59 percent. Analysis, including fitting of a log‐linear model, showed that increased probability of survival was associated with younger age at onset, nonadrenal site, and lower staging and that each of these factors acted independently. The sex of the child had no prognostic effect. This study thus extends earlier work by demonstrating the independent prognostic influence of site of tumor. The implications for treatment policy are discussed.