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Isolated marrow lymphoma: An entity of possible T‐cell derivation
Author(s) -
Barton James C.,
Conrad Marcel E.,
Vogler Larry B.,
Parmley Richard T.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19801015)46:8<1767::aid-cncr2820460812>3.0.co;2-5
Subject(s) - pancytopenia , medicine , bone marrow , lymphoma , pathology , hypoplasia , chemotherapy , lymphoproliferative disorders
Seven adults had a distinct clinicopathologic type of lymphoproliferative disorder of the bone marrow. All patients presented with weakness and pancytopenia; no evidence of gross extramedullary involvement was found. In 5 cases severe and prolonged bone marrow hypoplasia was associated with combination chemotherapy; 1 patient died of infection during initial therapy. In 6 of the 7 cases, clinical improvement occurred following therapy. As a terminal event, 2 patients developed a leukemic phase. Tumor cells from 4 patients were studied immunologically, and in 2 patients surface marker characteristics suggestive of T‐cell tumor origin were found. In 2 cases, ultrastructural studies of lymphoid cells were compatible with a T‐cell neoplasm. The above data suggest that these cases represent a distinct type of chemotherapy‐sensitive lymphoma in which conservative initial treatment may induce a response without prolonged bone marrow hypoplasia.