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Extramedullary plasmacytoma with gastric and lymph node involvement: An immunological study
Author(s) -
Preud'Homme JeanLouis,
Galian Annie,
Da Françoise,
Marti Raymond,
Rambaud JeanClaude
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19801015)46:8<1753::aid-cncr2820460809>3.0.co;2-z
Subject(s) - medicine , plasmacytoma , lymph node , procarbazine , prednisone , cyclophosphamide , vinblastine , pathology , vincristine , chemotherapy , multiple myeloma
A case of gastric and lymph node extramedullary plasmacytoma is reported in a young Algerian female. Treatment with cyclophosphamide was ineffective, but rubidazone, followed by a maintenance therapy with prednisone, procarbazine, and vinblastine induced a complete remission. Immunofluorescence studies and biosynthesis experiments in vitro showed that the tumor cells produced and secreted IgA‐ k molecules, whereas no monoclonal immunoglobulin could be found in the serum and gastric juice.