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Preliminary evaluation of intratumoral injection of a streptococcus pyrogenes preparation in patients with malignant brain tumors
Author(s) -
Tanaka Ryuichi,
Sekiguchi Kentaro,
Suzuki Yasuo,
Sobue Hachiki,
Ueki Komei
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19801001)46:7<1688::aid-cncr2820460731>3.0.co;2-l
Subject(s) - medicine , brain tumor , streptococcus pyogenes , streptococcus , surgery , pathology , radiology , biology , bacteria , genetics , staphylococcus aureus
Thirteen patients with malignant brain tumors, 12 anaplastic gliomas and one metastatic tumor, received repeated intratumoral injections of an immunopotentiator, Picibanil, prepared from streptococcus pyogenes. All patients tolerated this therapy; morbidity rates were acceptable. Significant tumor regression was noted on computerized tomography scanning for 6 of 12 patients for whom scanning was performed. Histologic examination of the post‐therapy specimens obtained from 8 patients revealed that inflammatory reactions were evoked in all of the tumors, although the extent of inflammatory changes varied from patient to patient and mostly was localized to an area surrounding the intratumoral tubes.