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Erythroblastic transformation in myeloproliferative disorders. Confirmation by an immunohistologic technique
Author(s) -
Neiman Richard S.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19801001)46:7<1636::aid-cncr2820460724>3.0.co;2-o
Subject(s) - erythroblast , myeloproliferative disorders , medicine , blast crisis , pathology , precursor cell , myeloid , metaplasia , hematological disorders , leukemia , myeloid leukemia , immunology , bone marrow , cell , erythropoiesis , biology , anemia , genetics
Blast crisis developed in 2 patients with myeloproliferative disorders, 1 with chronic granulocytic leukemia and the other with myelosclerosis and myeloid metaplasia. The blast cells had the morphologic and histologic characteristics of erythroblasts. An immunohistologic technique capable of detecting intracellular hemoglobin was used in order to demonstrate that these blast cells were of erythroid nature. The occurrence of erythroblast transformation in myelosclerosis and myeloid metaplasia as well as in chronic granulocytic leukemia supports the concept that both conditions are disorders of the marrow stem cell that may display similar morphologic, cytochemical and immunologic expressions in blast crisis. This study demonstrates that immunohistologic techniques are potentially valuable in the study of myeloproliferative disorders.