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Effect of human leukocyte interferon on the metastatic lung tumor of osteosarcoma. Case reports
Author(s) -
Ito Hidemoto,
Murakami Koichi,
Yanagawa Tetsuji,
Ban Shinjiro,
Sawamura Hiroji,
Sakakida Kisaburo,
Matsuo Akio,
Imanishi Jiro,
Kishida Tsunataro
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19801001)46:7<1562::aid-cncr2820460711>3.0.co;2-9
Subject(s) - medicine , osteosarcoma , interferon , lung , pathology , lung tumor , in vitro , cancer research , immunology , biology , biochemistry
Three patients with pulmonary metastases of osteosarcoma underwent treatment with intravenous or intramuscular administration of human leukocyte interferon. In 2 cases, the size of the metastasized tumor mass diminished temporarily six or eight months after interferon treatment, and serum alkaline phosphatase levels decreased to normal. In 1 case, the tumor cell from the pleural exudate I could be isolated and cultivated in vitro . When 2,000 IU of interferon was added to the tumor cell culture, marked inhibition of tumor cell growth resulted. In the other case, interferon had no effect on the metastasized lung tumor.