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Diffuse large cell lymphomas (reticulum cell sarcomas, histiocytic lymphomas). Correlation of morphologic features with functional markers
Author(s) -
Azar Henry A.,
Jaffe Elaine S.,
Berard Costan W.,
Callihan Thomas R.,
Braylan Raul R.,
Cossman Jeffrey,
Triche Timothy J.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800915)46:6<1428::aid-cncr2820460624>3.0.co;2-r
Subject(s) - null cell , endoplasmic reticulum , cytoplasm , pathology , lymphoma , histiocyte , cell , organelle , biology , antibody , microbiology and biotechnology , medicine , cell culture , immunology , biochemistry , genetics
Electron microscopic findings in 15 cases of diffuse large cell lymphoma were correlated with other morphologic features, surface immunotype and cytoplasmic immunoglobulin content. Immunologically, the cases were: B cell, 8; null, 4; T cell, 2; and H cell (true histiocytic), 1. Ultrastructurally, all B cell and three null lymphomas were characterized by an abundance of polyribosomes and segments of rough endoplasmic reticulum. Concentric rough endoplasmic reticulum was observed in 4 cases of B cell lymphoma containing cytoplasmic immunoglobulin and in a null lymphoma. In 1 case of B cell lymphoma, the diastase‐sensitive, periodic‐acid‐Schiff‐positive cytoplasm showed evidence of widely dispersed monoparticuiate glycogen granules. The two T cell lymphomas contained hyperlobulated or single round nuclei, and abundant smooth to rough endoplasmic reticulum. One null lymphoma appeared to share the ultrastructural features of T cell convoluted nuclei and the cytoplasmic organelles of myeloid precursor cells. The H cell lymphoma had features of monocytic‐macrophagic differentiation. The large cell lymphomas, a morphologically and functionally heterogeneous group, were represented predominantly in this series by neoplasms with follicular center cells or early plasma cells.