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Malignant pulmonary lymphoproliferative angiitis. A monoclonal neoplasm
Author(s) -
Lipper Stanley,
Wheeler Michael S.,
Jennette Charles
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800915)46:6<1411::aid-cncr2820460621>3.0.co;2-l
Subject(s) - pathology , medicine , lymphomatoid granulomatosis , autopsy , lymphoma , malignancy , bone marrow , malignant lymphoma , lymph , lymphoproliferative disorders
A 55‐year‐old female developed a rapidly fatal, infiltrative, bilateral pulmonary disease. Open lung biopsy and subsequent autopsy revealed diffuse involvement by a malignant lymphoproliferative condition showing a striking angiocentric and angioinvasive pattern. This feature, together with microscopic involvement of hilar lymph nodes, bone marrow, spleen, and other viscera suggested lymphomatous transformation of lymphomatoid granulomatosis (LYG). The paucity of necrosis and of the typical polymorphic infiltrate was at variance with the classical description of that condition; however, the bilaterality of the process and the distinctive angioinvasive growth pattern were unlike the typical primary pulmonary lymphoma. Plasmacytoid cells were observed both by light and electron microscopy. Immunohistochemical evaluation characterized this disease as a monoclonal lymphoproliferative malignancy.