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Squamous cell carcinoma arising in pemphigus vulgaris during immunosuppressive therapy
Author(s) -
Mahomed Yousef,
Mandel Mark A.,
Cramer Stewart F.,
Michel Beno
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800915)46:6<1374::aid-cncr2820460614>3.0.co;2-1
Subject(s) - pemphigus vulgaris , medicine , immunosuppression , prednisone , cyclophosphamide , basal cell , dermatology , pathogenesis , immunology , pathology , chemotherapy
A rapidly growing squamous cell carcinoma developed in an area of active pemphigus vulgaris on the cheek of a 45‐year‐old woman during treatment with prednisone and cyclophosphamide. This is the first reported case of this phenomenon. The roles of solar and drug carcinogenesis, autoimmunity, and immunosuppression in the pathogenesis of this tumor are discussed.